德诺苏马布对严重精子度的影响:随机对照试验
Sam Kafai Yahyavi1,2, Mads Joon Jorsal1, Signe Marie Wulff1
1Division of Translational Endocrinology, Department of Endocrinology and Internal Medicine, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
The Journal of clinical endocrinology and metabolism
|August 26, 2025
概括
骨质疏松症药物德诺苏马布在精子数量低的男性中没有改善精子度. 与安慰剂相比,该研究没有发现精子质量或生殖激素的显著差异.
科学领域:
- 生殖内分泌学
- 男性不孕症研究
- 药理干预措施
背景情况:
- 核因子卡帕-B连接体 (RANKL) 的受体激活剂与男性生殖有关.
- 丹诺苏马布是骨质疏松症的RANKL抑制剂,此前曾被建议用于改善精子质量.
- 需要进一步的研究来证实德诺苏马布在男性不孕症中的有效性.
研究的目的:
- 预期评估德诺苏马布对严重精子度的影响.
- 评估德诺苏马布治疗后生殖激素和丸大小的变化.
- 为了确定与安慰剂相比,德诺苏马布在改善精液参数方面是否具有更高的益处.
主要方法:
- 一个双盲,安慰剂控制,单中心随机临床试验.
- 42名患有小精子症的男性被随机分为2:1接受denosumab (60 mg) 或安慰剂80天.
- 主要终点是精子度的改善;次要终点包括荷尔蒙分析和精子数量.
主要成果:
- 在第80天的精子度或总精子数量之间没有显著差异.
- 没有观察到血清,LH,FSH,B抑制剂或AMH水平的显著变化.
- 两组患者的精子度和精子数量均比基线增加,不依赖于denosumab治疗.
结论:
- 在重症小精子症的男性中,使用denosumab并没有改善精子度或改变生殖激素的特征.
- 这项研究没有支持与安慰剂与维生素D和补充剂相比,德诺苏马布作为男性不孕症的优越治疗方法.
- 进一步的研究可能会探索男性因子不孕症的替代治疗点.
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