预产期早产和低出生体重的风险与三个月的特异性产前类药物暴露有关
Vincent Chin-Hung Chen1, Yi-Lung Chen1, Kai-Liang Kao1
1From the Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan (V.C.-H. Chen); Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan (V.C.-H. Chen); Department of Healthcare Administration, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Psychology, Asia University, Taichung, Taiwan (Y.-L. Chen); Department of Pediatrics, Far Eastern Memorial Hospital (Kao); School of Occupational Therapy, College of Medicine, National Taiwan University (Lee); Department of Psychiatry, Wan-Fang Hospital and School of Medicine, College of Medicine, Taipei Medical University (Lu); Department of Medicine, Mackay Medical College (Wu); Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan (Wu); Institute of Psychiatry, Psychology and Neuroscience, King's College London (Stewart); South London and Maudsley NHS Foundation Trust, London, UK (Stewart).
在怀孕的第三个三个月内使用二素显著增加了早产 (PTB) 和孕期婴儿 (SGA) 的风险. 早期孕期的暴露与这些不良分娩结果没有显著的关联.
科学领域:
- 产周医学
- 药理学
- 生殖健康
背景情况:
- 在怀孕期间使用二可能会导致胎儿的异常.
- 不同季度使用二对分娩结果的影响需要调查.
研究的目的:
- 评估怀孕期间二类药物暴露与早产 (PTB) 和怀孕年龄较小 (SGA) 婴儿的风险之间的联系.
- 确定二暴露时间 (按季度) 是否影响这些风险.
主要方法:
- 一项使用台湾国家医疗保险研究数据库 (2004-2016) 的13年纵向队列研究.
- 包括全人口,兄弟姐妹和父亲的比较.
- 分析了暴露或未暴露于二的活产儿,并对同一个母亲未暴露的怀孕进行了兄弟对照.
主要成果:
- 分析了超过480万例新生儿,发现仅在孕妇在孕期第三季度接触过二时,新生儿患PTB (OR 1.71) 和SGA (OR 1.47) 的风险显著增加.
- 在第一个或第二个月内没有发现二类药物暴露的显著联系.
结论:
- 第三个三个月内使用二与PTB和SGA的风险增加有关.
- 结果可能表明二对胎儿发育或子宫内环境有直接影响.
- 吸烟和父母精神疾病的严重程度是限制因素.
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