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Updated: May 2, 2026

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中枢神经系统参与和不参与的化学抗原受体T细胞治疗患者的生存结果的比较

Kenta Hayashino1, Nobuharu Fujii2, Satsuki Murakami3

  • 1Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan; Department of Hematology, Oncology and Respiratory Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan.

Clinical lymphoma, myeloma & leukemia
|August 26, 2025
PubMed
概括

化学抗原受体 (CAR) T 细胞疗法对涉及中枢神经系统的大型B 细胞淋巴瘤的疗效有限. 结果很差,尤其是中枢神经系统的二次淋巴瘤,这表明需要新的治疗策略.

关键词:
CAR T细胞治疗免疫效应器呼叫相关的神经毒性大型B细胞淋巴瘤在CAR T细胞治疗后提拉布鲁替尼

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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