在风湿性心脏病和退行性大动脉狭窄症中进行血清代谢分析
Daniel W Mutithu1,2,3, Jennifer A Kirwan4,5, Henry A Adeola6
1Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, and Groote Schuur Hospital, Cape Town, 7925, South Africa.
Scientific reports
|August 26, 2025
概括
在非洲患者中,METABOLOMICS确定了风湿性心脏病 (RHD) 和大动脉狭窄症 (AS) 的不同代谢生物标志物. 这些生物标志物与心脏重塑和炎症相关,为这些流行心血管疾病提供诊断潜力.
科学领域:
- 心血管疾病研究
- 代谢学
- 生物标志物发现
背景情况:
- 风湿性心脏病 (RHD) 和退行性大动脉狭窄 (AS) 是非洲普遍存在的心血管疾病 (CVD).
- 代谢学提供了一种强有力的方法来识别心血管疾病的致病和诊断生物标志物.
- 在撒哈拉以南非洲,对这些特定心脏病的代谢概况的研究有限.
研究的目的:
- 在非洲人群中研究严重的RHD和AS的分化代谢生物标志物.
- 进行门置换的RHD和AS患者的代谢概况与匹配的对照进行比较.
- 探索已识别的代谢物与心脏重塑参数之间的关联.
主要方法:
- 血清样本的非目标代谢分析.
- 患者组 (RHD,AS) 和健康对照组之间的代谢物概况比较.
- 统计分析以确定差异表达的代谢物和评估诊断精度 (AUC).
主要成果:
- 七种代谢物将RHD患者与对照患者区分开来 (AUC> 0. 7).
- 四种代谢物使AS患者与对照患者有区别 (AUC≥0. 7).
- 特定的代谢物 (7-HOCA,脱氧酸盐,甲酸,体,皮质醇) 与心脏功能 (排泄分数,质量指数) 和结有关.
结论:
- RHD和AS的代谢变化与心脏重塑,能量代谢,氨基酸通路和炎症有关.
- 在该群体中,已识别的代谢物显示为RHD和AS的诊断生物标志物.
- 这项试点研究强调了代谢学在代表性不足的地区了解心血管疾病的有用性.
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