结合circ_0054633和临床特征来预测儿童的耐火性Mycoplasma pneumoniae肺炎
Shiyin Mu1, Jia Zhai2, Yongsheng Guo1
1Department of Respiratory of Ma-Chang, Tianjin Children's Hospital, Tianjin University Children's Hospital, 225 Machang Road, Tianjin, 300074, China.
Scientific reports
|August 26, 2025
概括
结合circ_0054633表达与临床因子的新型诺摩图谱有助于在儿童中早期诊断耐火性Mycoplasma pneumoniae肺炎 (RMPP). 这种工具有望识别RMPP,改善患者的治疗结果.
科学领域:
- 儿童肺病学
- 分子诊断
- 生物标志物发现
背景情况:
- 在儿童中,耐火性Mycoplasma pneumoniae肺炎 (RMPP) 带来了诊断上的挑战.
- Circ_0054633是肺部感染的一个新兴生物标志物.
研究的目的:
- 开发和验证用于儿童早期RMPP诊断的诺姆图.
- 评估circ_0054633与临床特征相结合的预测效果.
主要方法:
- 在244名患有Mycoplasma pneumoniae肺炎 (MPP) 的儿童中进行了回顾性研究.
- 多变量分析以确定RMPP的独立预测因素.
- 使用AUC和校准构建和验证Nomogram.
主要成果:
- 鉴定了六种独立预测因素:高血循环,持续发烧,低氧化,肺外并发症,高IL-6和乳腺增生.
- 这种分辨率非常好 (AUC=0.920).
- RMPP患者住院时间较长,需要更多的干预措施.
结论:
- 一个基于circ_0054633的nomogram有效地预测了儿童的RMPP.
- 血清circ_0054633是一个有前途的RMPP新型诊断生物标志物.
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