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可编程自我复制的JEV纳米疗法重新定义了ALS中的RNA输送

Yan Shan Loo1, Nur Aininie Yusoh2, Keyin Yap1

  • 1School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Selangor, Malaysia.

Communications biology
|August 26, 2025
PubMed
概括

设计的日本脑炎病毒 (JEV) 可以向运动神经元输送反感性寡核酸 (ASO),用于治疗肌缩侧面硬化症 (ALS). 这种新的纳米载体策略旨在通过血脑屏障进行有针对性的,持续的基因治疗.

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