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Updated: Sep 10, 2025

Assay Development for High Content Quantification of Sod1 Mutant Protein Aggregate Formation in Living Cells
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由导致ALS的SOD1突变G93A和D101N形成的明显的粉状纤维结构

Mu-Ya Zhang1, Yeyang Ma2,3, Li-Qiang Wang4

  • 1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, 430072, Wuhan, China.

EMBO reports
|August 26, 2025
PubMed
概括

肌缩侧面硬化 (ALS) 与SOD1突变有关. 化EM结构显示出不同的G93A和D101N突变SOD1粉状纤维的形成,G93A纤维具有更高的毒性.

关键词:
粉状纤维肌缩侧面硬化症 (ALS)化电磁结构SOD1 突变体有毒性

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