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Updated: Sep 10, 2025

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
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Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

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深度MVP:在高质量的数据上训练的深度学习模型准确预测PTM站点和变异引起的变化

Bo Wen1,2,3, Chenwei Wang1,2, Kai Li1,2,4

  • 1Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.

Nature methods
|August 26, 2025
PubMed
概括

研究人员开发了PTMAtlas和DeepMVP以预测蛋白质的翻译后修饰 (PTM). 这种深度学习方法准确地识别了改变PTM的变体,进步了疾病机制的理解.

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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