癌症幸存者的身体活动,绩效和临床试验入学之间的关联
Kelsey E Maslana1, Ryan D Burns1, Paul A Estabrooks1
1Department of Health and Kinesiology, University of Utah, 2000 Circle of Hope Drive, Research South Building RM 4747, Salt Lake City, UT, 84112, USA.
BMC cancer
|August 26, 2025
概括
癌症幸存者的身体活动与更好的身体功能有关. 具体来说,Light PA可能有助于医生评估东部合作性瘤组 (ECOG) 的绩效,影响治疗决策和临床试验资格.
科学领域:
- 癌症学
- 运动科学
- 临床研究
背景情况:
- 研究患者报告的体力活动 (PA) 与医生评估的体力表现得分 (ECOG) 之间的关系.
- 检查PA水平与实验治疗临床试验的入学人数之间的关联.
研究的目的:
- 确定患者报告的习惯性体力活动是否与医生评估的东部合作性瘤组 (ECOG) 绩效状况相关.
- 探索癌症幸存者身体活动水平与临床试验资格之间的联系.
主要方法:
- 总癌症护理 (TCC) 队列 (2016-2022) 的二次数据分析.
- 使用修改的戈丁问卷评估每周的AP; ECOG分数分为"好" (0-1) 或"差" (2-4).
- 根据人口统计和癌症特征调整的二进制后勤回归分析了与ECOG评级和临床试验招生相关的PA水平.
主要成果:
- 在未调整和调整的模型中,较高的轻度体力活动水平与具有良好的ECOG评级的可能性更高.
- 在中度至强度的PA和ECOG评分之间没有发现统计学意义上的关联,也没有发现整体PA和临床试验入学率之间的关联.
- 该研究包括603名癌症幸存者,主要是女性 (51%),非西班牙裔 (95%) 和白人 (95%),平均年龄为61. 9岁.
结论:
- 患者报告的轻度体力活动可能是医生确定ECOG评级的有用工具.
- 鉴于其在治疗决策和临床试验资格方面的重要性,需要进一步的研究来确定以患者为中心的工具,以补充医生评估的ECOG分数.
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