增加皮肤自发光预测未来的癌症发展
Henderikus E Boersma1,2, Grigory Sidorenkov3, Andries J Smit2
1Department of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30001, HPC AA31, Groningen, 9700 RB, the Netherlands.
BMC cancer
|August 26, 2025
概括
较高的皮肤自光 (SAF) 是组织糖化标志物,与癌症风险增加有关. 即使调整了各种健康因素,这种关联仍然显著,这表明SAF
科学领域:
- 生物医学
- 癌症学
- 内分泌学
背景情况:
- 通过皮肤自光 (SAF) 测量组织糖化,与2型糖尿病 (T2D),心血管疾病 (CVD) 和死亡率的风险增加有关.
- 之前的研究表明,高SAF水平与癌症发病率之间存在潜在联系.
研究的目的:
- 研究SAF与新癌症诊断的时间之间的关系.
- 在一个有或没有T2D的大型群体中评估这一关联.
主要方法:
- 利用来自北荷兰的生命线队列研究 (2006-2013) 的数据,将参与者数据与荷兰全国病理数据库 (Palga) 联系起来.
- 包括77,961名参与者 (有或没有T2D),在基线无癌症,随访时间平均为11. 5年.
- 为了评估SAF与癌症发病率之间的关联,使用了考克斯的比例危险分析.
主要成果:
- 较高的SAF与总体癌症发病率的增加有显著联系 (HR 2. 36).
- 这种关联在男性中比女性更强,在多变量调整后仍然显著 (HR 1. 11).
- 增加的SAF与特定的癌症有关,包括肺癌,食道癌,尿道癌,卵巢癌,女性生殖器癌和肝癌.
- 在患有T2D的参与者中,较高的SAF与癌症发病率的增加有关,尽管在完全调整后,这种情况没有达到统计学意义.
结论:
- 较高的SAF测量与癌症发病率略有增加有关,而这与糖尿病状况无关.
- 不仅用于糖尿病和心血管疾病风险,还用于癌症风险评估.
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