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蛋白质组学在肥胖中的全球现状和趋势:一个文献分析和知识图表研究

Xiaoying Wu¹, Yongming Chen², Tong Wu³

¹Department of Endocrinology, Beijing Hospital, Peking University Fifth School of Clinical Medicine, National Center of Gerontology, Beijing, China.

Tropical medicine and health

|August 27, 2025

概括

肥胖的蛋白质组学研究显著扩大,将重点从基本生物学转移到肠道微生物群等系统因素,并与临床应用联系起来. 这一趋势凸显了科学优先事项的发展和全球对肥胖问题的理解.

科学领域:

• 蛋白质组学和肥胖研究
• 代谢疾病的分子机制

背景情况:

• 蛋白质组学对于了解肥胖的分子基础至关重要.
• 这一领域在过去二十年中经历了实质性的增长和不断发展的研究主题.

研究的目的:

• 绘制肥胖蛋白质学研究的全球趋势.
• 确定主要贡献者并分析不断发展的主题.
• 审查1999年至2025年该领域的发展情况.

主要方法:

• 从科学网络核心集合 (1999-2025) 中对1688个出版物的图书统计分析.
• 使用CiteSpace和VOSviewer分析出版物数据,协作和关键词.
• 包含英语原创文章和评论.

主要成果:

•出版量稳步增长,在2022年达到顶峰.
• 美国是最大的贡献者,其次是中国和德国.
• 研究主题从脂肪生物学转移到肠道微生物群,脂质新陈代谢,2型糖尿病和PCOS,反映了向系统机制和临床应用的转变.

结论:

• 肥胖蛋白质组学研究的规模和复杂性正在增加.
• 全球合作和科学优先事项正在发展.
• 这些发现为未来的转化和跨学科肥胖研究提供了方向.

关键词:

图书识别技术引用空间肥胖问题蛋白质组学在VOS的观众

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