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Updated: Sep 10, 2025

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通过降低YAP1表达,KLF11通过调节M1巨分化来缓解类风湿性关节炎

Xiaodan Liu1, Fang Fang2, Hongmei Duan2

  • 1Clinical Laboratory Department, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.

Arthritis research & therapy
|August 27, 2025
PubMed
概括

这项研究表明,KLF11在类风湿性关节炎 (RA) 中受到下调. 通过抑制M1巨分化和ERK通路,增加RA模型中的KLF11水平可以降低疾病的严重程度和骨损伤.

关键词:
ERK信号通道克鲁佩尔类因子11巨细胞的两极分化类风湿性关节炎是的相关蛋白1

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