赛德纳姆胆核中的单细胞RNA测序显示B细胞HLA-DR/DQ上调和血细胞蛋白质激活
Velda X Han1,2,3, Brooke A Keating1, Brian S Gloss4
1Kids Neuroscience Centre, The Children's Hospital at Westmead, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Annals of clinical and translational neurology
|August 27, 2025
概括
西登汉病变的发病原因尚不清楚. 单细胞RNA测序揭示了免疫细胞路径的改变,支持这种罕见的神经疾病的B细胞介导自身抗体假设.
科学领域:
- 免疫学
- 基因组学
- 罕见疾病
背景情况:
- 这种神经疾病的确切原因尚不清楚.
- 这项研究研究了一位患有Sydenham胆固醇炎的患者的免疫细胞概况.
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