盆腔外辐射治疗对儿科患者下尿路功能的影响
Michael H Edwards1, Andrew Nicklawksi2, Gemma Beltran3
1Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, Colorado, USA.
Pediatric blood & cancer
|August 27, 2025
概括
接受盆腔放射治疗的儿童癌症幸存者表现出下游尿路功能异常,特别是高原形尿流模式和空气后残留物增加. 在这个群体中,功能障碍排泄评分系统不是一个有用的查工具.
科学领域:
- 儿童瘤学
- 泌尿外科
- 辐射瘤学
背景情况:
- 在儿童癌症幸存者中,多种治疗对下尿路功能的长期影响尚未得到充分描述.
- 外部辐射疗法 (EBRT) 是对儿童固体瘤的常见治疗方法,通常涉及骨盆区域.
- 了解骨盆EBRT对LUT功能的影响对于幸存者护理至关重要.
研究的目的:
- 研究盆腔外辐射疗法 (EBRT) 对儿童癌症幸存者的下尿道功能的影响.
- 为了比较患者报告的结果,非侵入性泌尿动力学研究,以及接受骨盆EBRT和不接受的CCS后残留量 (PVR).
主要方法:
- 对儿童固体瘤进行超过1年的CCS前性队列研究.
- 根据盆腔EBRT暴露被分为群体.
- 评估包括功能障碍排泄评分系统 (DVSS) 调查,尿液流量测试和排泄后残留 (PVR) 膀扫描.
主要成果:
- 盆腔辐射队列显示出异常尿流模式 (81%对56%) 和异常PVR (OR 9. 0, p = 0. 002) 的可能性更高.
- 尿流模式的分布在各组之间有显著差异 (p = 0.03),辐射队列更有可能呈现"平原"形状的曲线 (44%对6%).
- 探索性分析表明盆腔EBRT剂量与LUT功能障碍之间存在潜在的关联.
结论:
- 在接受盆腔辐射治疗的儿童癌症幸存者中,外辐射疗法 (EBRT) 似乎对下尿路功能产生负面影响.
- 功能障碍排泄评分系统 (DVSS) 在这个群体中可能不是敏感的LUT功能障碍查工具.
- 需要进一步的研究来阐明EBRT对LUT功能的全部影响,并开发改进的查方法.
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