Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Nature-inspired design of carbon dots for multifunctional applications in 6-mercaptopurine sensing, bioimaging, and bacterial growth promotion.

Nanoscale·2026
Same author

Differential regional textural attributes of tongue in normal and acidity patients in the light of traditional Chinese medicine.

Computers in biology and medicine·2026
Same author

Pilot Study on the Efficacy and Safety of Thalidomide in Transfusion-Dependent and Non-transfusion-Dependent Thalassemia: A Prospective, Non-randomized Interventional Study.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2026
Same author

Author Correction: HLA polymorphisms shape divergent outcomes of Toxoplasma and Plasmodium infection in Eastern Indian HbE/β-thalassemia cohort.

Communications biology·2026
Same author

HLA polymorphisms shape divergent outcomes of Toxoplasma and Plasmodium infection in Eastern Indian HbE/β-thalassemia cohort.

Communications biology·2026
Same author

<i>In Vivo</i> Drug-Eluting Smart Scaffold for Diabetic Wounds.

ACS applied materials & interfaces·2026

相关实验视频

Updated: Sep 10, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.2K

生物工程芯片模型用于磁纳米粒子驱动的向癌症治疗

Dhruba Dhar1, Debolina Manna1, Sampad Laha2

  • 1School of Medical Sciences and Technology, Indian Institute of Technology (IIT) Kharagpur, Kharagpur 721302, India.

ACS applied materials & interfaces
|August 27, 2025
PubMed
概括
此摘要是机器生成的。

研究人员开发了一种新的芯片模型,以克服磁性药物向 (MDT) 研究的局限性. 这种仿生系统精确地模仿瘤微环境,使得可以更好地评估用于癌症治疗的磁性药物载体 (MDC).

关键词:
三维细胞模型节的微流体磁性药物向纳米医学在芯片上的瘤

更多相关视频

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.8K
Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

486

相关实验视频

Last Updated: Sep 10, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.2K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.8K
Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

486

科学领域:

  • 生物医学工程
  • 纳米技术
  • 癌症学

背景情况:

  • 磁性药物向 (MDT) 面临临临床障碍,包括磁场减弱和缺乏准确的疾病模型.
  • 现有的模型无法复制瘤微环境 (TME) 和细胞对磁性刺激的反应.

研究的目的:

  • 在生理相关的瘤微环境中开发一种新的芯片模型来评估磁性药物载体 (MDC).
  • 解决目前MDT研究模式的局限性,包括动物和合成平台.

主要方法:

  • 一种无 lithography 制造方法创建了一个仿生乳房 TME 模型,其中包含了 MDA-MB-231 细胞在水凝和 HUVEC 层的微通道中.
  • 在不同磁场和剪切应力下测试了桑涂层的MDC (10-20nm).
  • 活体/死体测定,免疫细胞化学,流细胞测量和基因表达分析评估了药物的有效性和细胞反应.

主要成果:

  • 芯片上的模型成功复制了TME条件,使得MDC准精确的磁场校准.
  • 磁性向药物表现出剂量依赖的作用,诱导细胞亡并减少侵袭标志物.
  • 该系统有助于对磁场强度和剪切应力进行MDC保留的评估.

结论:

  • 开发的生物工程芯片是MDT研究的成本高效,可扩展和仿生平台.
  • 这种新的系统能够对抗癌症疗法进行临床前查,并促进磁性向策略的优化.