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Updated: Sep 10, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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通过抑制TGF-β信号,ERBIN限制了上皮细胞的可塑性

Chao Li1, Gerard van der Zon1, Peter Ten Dijke1

  • 1Oncode Institute and Department of Cell & Chemical Biology, Leiden University Medical Center (LUMC), The Netherlands.

FEBS letters
|August 27, 2025
PubMed
概括

通过抑制转化生长因子-β (TGF-β) 和表皮生长因子受体 (EGFR) 信号传递,ERBIN抑制了表皮转化为介质细胞的转化 (EMT). 这种蛋白质是细胞迁移和癌症进展的关键调节者.

关键词:
美国表皮生长因子受体从上皮细胞转变为介质细胞细胞外信号调节激酶信号传输转化生长因子-β

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