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来自Garcinia mangostana的细胞毒性代谢物

Abdullah I R Alanazi¹, Hossam M Abdallah^1,2, Hagar M Mohamed^3,4

¹Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.

Journal of pharmacy & bioallied sciences

|August 27, 2025

概括

作为抗癌剂的 Garcinia mangostana 化合物是有前途的. 在实验室中,Garcinone D和alpha- mangostin对卵巢,肝脏和结直肠癌细胞系具有显著的细胞毒性作用.

科学领域:

植物化学
药理学
癌症研究

背景情况:

在东南亚医药中用于感染和伤口的传统使用.
主要的生物活性成分被确定为桑和化合物.
桃花及其代谢物具有多种生物活性.

研究的目的:

从Garcinia mangostana pericarp中分离和识别生物活性化合物
评估隔离化合物的体内细胞毒性对各种癌细胞系的影响.
确定潜在的化合物用于抗癌药物开发.

主要方法:

用甲醇提取Garcinia mangostana pericarp,然后进行溶剂分离和染色学净化.
使用NMR和文献数据分离和鉴定了六种化合物:α-曼戈斯,β-曼戈斯,加尔坦,加尔辛C,加尔辛D和阿斯蒂尔宾.
使用硫胺B (SRB) 测定对卵巢 (SKOV- 3),肝脏 (HepG- 2) 和结直肠 (HCT- 116) 癌细胞系进行体外细胞毒性评估,用多克索鲁比作为阳性对照.

主要成果:

所有分离的化合物都表现出不同程度的细胞毒性.
Garcinone D对SKOV-3细胞具有显著的细胞毒性 (IC50 27. 27 ± 2. 41μM).
阿尔法-曼戈斯和β-曼戈斯对HepG-2细胞具有细胞毒性 (IC50分别为28. 1±1.1μM和31. 9±10. 7μM).
贝塔- 曼戈斯和加辛D对HCT-116细胞具有细胞毒性作用 (IC50分别为56. 1±2.5μM和44. 3±2.5μM).

结论:

加尔西尼亚曼戈斯塔纳周围植物具有显著的细胞毒性.
Garcinone D和alpha-mangostin被认为是进一步开发抗癌药物的有希望的化合物.
这项研究证实了Garcinia mangostana衍生品在癌症治疗研究中的潜力.

关键词:

甘果类植物细胞毒性黄类的健康与福祉健康与福祉剥皮的类子

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