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Updated: Sep 10, 2025

Analysis of Protein Folding, Transport, and Degradation in Living Cells by Radioactive Pulse Chase
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Published on: February 12, 2019

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折叠校正器与CFTR中第一个二元化核酸结合域之间的热力学合

Guangyu Wang1,2

  • 1Department of Physiology and Membrane Biology, University of California School of Medicine, Davis, California 95616, United States.

ACS bio & med chem Au
|August 27, 2025
PubMed
概括

囊性纤维化校正剂保护α子域,恢复蛋白质折叠并使二分化成为可能. 这种机制可以治疗F508del和其他罕见的囊性纤维化突变.

关键词:
异构路径合作折叠能源景观化的门非共价热结构保护性折叠蛋白质稳定性

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