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相关概念视频

Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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相关实验视频

Updated: May 6, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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用于乳腺癌治疗的升级转化纳米粒子

Shijing Wang1,2, Lei Zhang1, Minghao Wang3

  • 1Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110000, China.

Theranostics
|August 27, 2025
PubMed
概括

通过使用近红外光进行深度成像和治疗,工程上转化纳米粒子 (UCNPs) 提供了乳腺癌 (BC) 的先进疗法. 这些纳米颗粒可以实现综合诊断和治疗功能,改善BC管理.

关键词:
生物标志物检测乳腺癌交付时间免疫疗法分子成像光疗法预测技术上转化纳米粒子

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科学领域:

  • 纳米技术
  • 生物医学工程
  • 癌症学

背景情况:

  • 乳腺癌是全球主要的健康问题,需要创新的诊断和治疗策略.
  • 稀土 (RE) 添加的上转化纳米粒子 (UCNPs) 具有独特的生物医学应用的光物理特性.
  • 与传统探针相比,UCNP具有优势,包括通过近红外 (NIR) 光吸收的深层组织透和减少自身光.

研究的目的:

  • 提供针对乳腺癌的UCNP综合审查.
  • 总结UCNP合成,功能化和生物评估的最新进展.
  • 探索UCNP在BC分子成像,检测,治疗和免疫治疗中的多样化应用.

主要方法:

  • 审查UCNP合成,包括发光机制和可控制的方法.
  • 对UCNP表面修改策略进行分析,以实现有针对性的交付和多功能.
  • 系统评估UCNP的生物效应 (生物分布,新陈代谢,生物毒性) 和神经应用.

主要成果:

  • 工程UCNPs可以整合诊断和治疗模块进行全面的BC治疗.
  • 通过吸收NIR光线,UCNP促进深层组织成像和向治疗.
  • 最近的研究表明UCNP在BC分子成像,生物标志物检测,光疗,药物/基因输送和免疫疗法中的有效性.

结论:

  • 工程UCNPs代表了高级乳腺癌治疗的多功能平台.
  • 进一步研究UCNP的生物效应和临床转化对于广泛采用至关重要.
  • 在改善乳腺癌诊断,治疗和患者的治疗结果方面,UCNP具有显著的前景.