作为乳腺癌无转移生存的生物标志物的瘤免疫反应和免疫检查点抑制疗法:回顾性队列研究
Chung-Wu Lin1, Kai-Ming Chang1, Wen-Hui Ku2
1Department of Molecular Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei City, Taiwan.
Breast cancer : basic and clinical research
|August 27, 2025
概括
瘤免疫反应 (IR) 在特定的乳腺癌 (BRC) I,II和IV亚型中显著影响无转移存活率 (MFS). 这一IR得分可以帮助确定可以从免疫检查点抑制疗法 (ICIT) 中受益的患者.
科学领域:
- 癌症学
- 免疫学
- 基因组学
背景情况:
- 乳腺癌 (BRCs) 根据基因表达表现出6种分子亚型.
- 瘤透的淋巴细胞与三阴性和HER2过度表达的BRC的无转移存活率 (MFS) 有关.
研究的目的:
- 调查免疫反应 (IR) 对不同BRC分子亚型的MFS的影响.
- 开发和验证BRC患者的IR得分.
主要方法:
- 追溯性队列研究分析327个BRC用于IR转录的识别和分组为高/低响应者.
- 基于297个IR成绩的成绩.
- 在独立数据集 (884和988BRC) 中验证IR得分及其与已确定的IR特征和免疫检查点基因表达的相关性.
主要成果:
- 在培训,确认和验证系列中,高免疫反应者在BRC亚型I,II和IV中显著改善了MFS.
- 红外线分数与已确定的红外线特征和免疫检查点基因表达线性相关.
- 卡普兰-梅尔生存分析和日志排名测试证实了IR和MFS之间的关联.
结论:
- 在BRC亚型I,II和IV中,瘤IR作为MFS的生物标志物.
- 开发的IR评分显示了可能对免疫检查点抑制疗法 (ICIT) 有反应的患者的识别潜力.
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