维生素C在患有远端半径骨折的患者中复杂的区域疼痛综合征
Fernando Antonio Silva de Azevedo Filho1,2, Roberta Muniz Blunck1, Abdouni Y Ali3
1Hospital do Subúrbio, Salvador, Bahia, Brazil.
Revista brasileira de ortopedia
|August 27, 2025
概括
维生素C补充剂显著降低了因远端半径骨折而接受手术的患者的复杂区域疼痛综合征 (CRPS) 和神经病痛的发生率. 这种干预也改善了术后疼痛控制.
科学领域:
- 整形医学
- 治疗疼痛
- 营养科学
背景情况:
- 复杂区域性疼痛综合征 (CRPS) 是可能发生在骨折后的衰弱性疾病.
- 半径末端骨折 (FDER) 很常见,可能导致严重的疼痛和残疾.
- 营养干预在预防CRPS和治疗术后疼痛方面的作用是正在进行的研究领域.
研究的目的:
- 调查维生素C在半径骨折的远端进行手术后预防CRPS的有效性.
- 评估维生素C对神经病痛发生率和严重性的影响.
- 评估维生素C对整体术后疼痛控制的影响.
主要方法:
- 进行了一项随机对照试验,涉及需要手术的FDER成年患者.
- 在手术后的60天内,参与者被分配给每天1g的维生素C或安慰剂.
- 测量结果包括CRPS发病率,神经病痛 (使用VAS) 和不同时间点的疼痛得分.
主要成果:
- 与安慰剂组相比,维生素C组中神经性疼痛的发生率明显较低 (p=0. 008).
- 接受维生素C治疗的患者报告了较低的视觉模拟度 (VAS) 平均疼痛分数 (p=0. 001).
- 在维生素C干预组中,12周和24周的CRPS发病率在统计上较低 (分别为p=0. 014和p=0. 007).
结论:
- 维生素C在远端半径骨折后预防复杂区域疼痛综合征 (CRPS) 的作用显著.
- 维生素C补充剂有效降低神经性疼痛的发生率,并改善术后疼痛管理.
- 这项研究支持使用维生素C作为FDER患者的辅助疗法来缓解疼痛和预防CRPS.
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