评估局部麻醉剂与根牙连续化作用的相互作用 - 一个"体外"研究
Lokhasudhan Govindaraju1, Sangkeetha Gnanasekaran1, Mathan Rajan Rajendran1
1Department of Conservative Dentistry and Endodontics, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research (SRIHER - DU), Chennai, Tamil Nadu, India.
在根管治疗过程中,使用2%的lignocaine HCl和顺序灌 (低酸和EDTA) 产生的碎片最少. 在4%的Articaine HCl中观察到较高的碎片含量.
科学领域:
- 牙周内科
- 牙科材料科学
- 局部麻醉
背景情况:
- 在不响应的牙中,注射局部麻醉剂 (LA) 对于根管治疗至关重要.
- 对于LAs和内灌剂之间的相互作用尚不清楚.
- 对于程序安全来说,研究LA与灌剂相互作用的碎片形成至关重要.
研究的目的:
- 在局部麻醉溶液与内牙灌剂相互作用时评估碎片的形成.
- 使用不同局部麻醉剂 (利格诺卡因HCl与阿尔蒂卡因HCl) 进行碎片形成比较.
- 评估灌方案 (顺序或连续化) 对碎片的影响.
主要方法:
- 使用了16个单根人类下前.
- 使用2%的利格诺卡因HCl或4%的阿尔蒂卡因HCl进行了内麻醉.
- 牙用3%的酸盐 (NaOCl) 和17%的乙烯基二胺三酸 (EDTA) 或NaOCl用1-乙烯-1,1-二酸 (HEDP) 灌,然后进行扫描电子显微镜 (SEM) 分析.
主要成果:
- 在SEM分析中,使用2%的利格诺卡因HCl和顺序灌 (NaOCl和EDTA) 形成了最少的碎片.
- 根部的顶部三分之一显示出所有组的碎片数量显著增加.
- 与2%的利格诺卡因HCl相比,4%的Articaine HCl总是导致更多的碎片积累.
结论:
- 使用NaOCl和EDTA的顺序灌可以在使用2%的lignocaine HCl时减少碎片的形成.
- 与连续灌相比,使用NaOCl和HEDP的连续化会产生更多的碎片.
- 无论使用的灌方案如何,4%的Articaine HCl都会增加碎片的形成.
相关概念视频
Local Anesthetics: Mechanism of Action
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
Local Anesthetics: Chemistry and Structure-Activity Relationship
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia


