在急性和慢性不可逆转的肺炎中对抗生素耐药性基因进行分子分析:横截面研究
Preethesh Shetty1, Raksha Bhat1, Shruthi Padavu2
1Department of Conservative Dentistry and Endodontics, AB Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be University), Mangalore, Karnataka, India.
Journal of conservative dentistry and endodontics
|August 27, 2025
概括
抗生素耐药性基因在不可逆转的肺炎中很常见,尤其是在急性病例中. 这突显了对抗生素耐药性进行更好的管理的必要性.
科学领域:
- 牙周内科
- 微生物学
- 分子生物学
背景情况:
- 抗菌药物耐药性是一个全球性的健康危机.
- 在口腔微生物群中存在抗菌基因.
- 尽管有指导方针, 抗生素对不可逆转的肺炎的过度使用却很普遍.
研究的目的:
- 评估急性和慢性不可逆转乳房炎中β-乳酸盐和四环素耐药基因的流行率.
- 提供分子证据支持临床指南反对实证抗生素使用.
主要方法:
- 从24名患者 (12例急性,12例慢性不可逆性肺炎) 采集了皮质组织样本.
- 提取DNA并使用PCR检测tetA,tetB,blaTEM和blaCTX基因.
- 通过凝电泳和序列分析进行分析.
主要成果:
- 在54.2%的样本中发现抗生素耐药性基因.
- 在急性 (66. 7%) 和慢性肺炎 (41. 7%) 中的患病率更高.
- 在急性病例中,抗药性基因和抗药性基因的同时发生率显著增加.
结论:
- 抗生素耐药性基因在肺部感染中非常普遍.
- 这些发现支持针对不可逆转的肺炎的常规抗生素处方的指导方针.
- 强调需要对抗生素管理和内牙科的抗药性监测.
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