球形投影对脑图的旋转测试的影响
Vincent Bazinet1, Zhen-Qi Liu1, Bratislav Misic1
1McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, Canada.
Imaging neuroscience (Cambridge, Mass.)
|August 27, 2025
概括
用于脑图比较的旋转测试可以由于球形投影的几何扭曲而增加假阳性率. 删除扭曲的旋转可以提高神经成像分析的准确性.
科学领域:
- 神经成像
- 计算神经科学
- 大脑映射
背景情况:
- 脑图的统计比较在神经成像研究中至关重要.
- 空间自相关性是评估地图相似性的关键因素.
- 旋转测试是生成替代大脑图的一个常见方法.
研究的目的:
- 调查球形投影对旋转测试准确性的影响.
- 为了识别产生替代大脑图的错误来源.
- 提出提高地图对地图比较可靠性的方法.
主要方法:
- 通过将大脑地图投射到球形表面来分析引入的几何扭曲.
- 通过旋转测试生成的替代地图中空间自相关性保存的评估.
- 在地图对地图相似性测试中评估假阳性率.
- 识别和删除扭曲旋转的方法.
主要成果:
- 球形投影扭曲了大脑地图中的顶点距离关系.
- 这些扭曲导致替代地图中不完美的空间自相关性保存.
- 通常使用的旋转测试会产生膨胀的假阳性率.
- 针对性地去除高度扭曲的旋转可以显著降低假阳性率.
结论:
- 准确的皮质几何表示对于有效的旋转测试应用至关重要.
- 球体投影中的几何扭曲损害了替代地图的完整性.
- 通过解决几何扭曲来改进旋转测试方法,提高神经成像统计比较的可靠性.
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