通过 Captisol® (β- 环素硫乙烯) 包含复合物在口腔溶解膜中的增强溶解性和快速递送维生素D3
Sultana Essa Bin Haider1, Sharav Desai2, Aliasgar F Shahiwala1
1Department of Pharmaceutical Sciences, College of Pharmacy, Dubai Medical University, Dubai, UAE.
Advances in pharmacological and pharmaceutical sciences
|August 27, 2025
概括
这项研究使用Captisol®包容复合物和口腔溶解膜 (MDF) 提高了维生素D3的溶解度. 这种新的方法改善了药物输送,
科学领域:
- 制药科学
- 药物输送系统
- 材料科学
背景情况:
- 维生素D3缺乏是一个普遍的健康问题.
- 维生素D3的脂性和水溶性不佳阻碍了其制药配方和生物可用性.
- 开发像维生素D3这样的可溶性较低的药物的有效输送系统至关重要.
研究的目的:
- 通过与Captisol® (β-环氧衍生物) 形成含有复合物来增强维生素D3的溶解性.
- 开发一种患者友好的口腔溶解膜 (MDF),以改善维生素D3的输送.
- 评估开发的含有维生素D3的MDF的物理化学,机械和感官特性.
主要方法:
- 使用绿色微波辅助技术制备维生素D3-Captisol®注入复合物
- 通过分子对接,相溶性研究,药物加载和FTIR光谱进行复合物的表征.
- 构建和评估采用优化的包装复合物的MDF,评估分解,溶解,内容均性和机械强度.
主要成果:
- 分子对接表明维生素D3和Captisol®之间具有强烈的结合亲和力 (-10.7K·mol-1).
- 维生素D3与Captisol®的最佳分离比为2:1.
- 优化的MDF表现出快速的分解 (36秒) 和溶解 (在5分钟内完全释放),内容均性很好 (98.8%).
结论:
- 为准备维生素D3-Captisol®注入复合物而建立了一种新的环保方法.
- 开发的MDF提供了一种有效且对患者友好的维生素D3输送方法.
- 这种配方策略有望通过提高维生素D3的可溶性和输送来提高维生素D3的治疗效果.
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