在炎症性肠病的发病过程中以素为中心的观点
Toshihiro Tomii1, Gen Kano1,2
1Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Frontiers in allergy
|August 27, 2025
概括
在炎症性肠病 (IBD) 中,氨基酸具有双重作用,有助于炎症和修复. 针对西格莱克-8和反应性氧物种 (ROS) 等乙酸细胞通路,可以恢复肠道健康.
科学领域:
- 胃肠道免疫学
- 粘膜免疫力
- 炎症性肠病 (IBD) 的研究
背景情况:
- 氨基酸 (Eos) 越来越多地被认为是胃肠道免疫调节中的作用,特别是在IBD中.
- 在IBD中,血液和肠道组织中高氨基酸水平是常见的,但它们的功能仍未得到充分研究.
研究的目的:
- 重新研究乙酸在IBD病变中的作用.
- 整合最近关于粘膜免疫和组织平衡的洞察力.
- 突出表现出埃索诺菲尔从纯粹的炎症效应因子转变为炎症和修复的调节者.
主要方法:
- 对与IBD活性相关联的临床和实验发现的审查.
- 在维护肠道屏障完整性方面分析来自乙酸的活性氧物种 (ROS) 的调节功能.
- 检查Siglec-8抑制受体通路及其可能受到饮食因素的影响.
主要成果:
- 乙氨基的丰度,激活和颗粒蛋白释放与IBD疾病活性相关.
- 与过氧化一样,由乙氨基酸衍生的ROS对于肠道屏障的完整性至关重要,因而导致炎症的恶化.
- 红肉中发现的非人性酸 (Neu5Gc) 可能会影响涉及酸的Siglec-8通路,这可能会影响酸细胞的调节.
结论:
- 在IBD中具有双重作用,作为炎症和修复细胞.
- 通过调节氨基酸活性,针对Siglec-8和ROS平衡提供了IBD的潜在治疗策略.
- 失调的乙素激活和上皮屏障功能障碍可能是IBD和过敏疾病之间的共同机制.
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