炎症免疫营养 (IINS) 评分对乳腺癌患者术后生存和复发的意义:一项回顾性研究
Yuan Wang1, Wenxin Gao2, Shan Wang1
1Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, China.
PeerJ
|August 27, 2025
概括
与传统标志物相比,炎症免疫营养评分 (IINS) 是乳腺癌患者存活率的最佳预测指标. 这一分数可以更准确地评估术后的结果和复发风险.
科学领域:
- 癌症学
- 免疫学
- 营养科学
背景情况:
- 瘤发生,进展和转移受炎症,免疫状况和营养因素的影响.
- 评估预后标记对于优化乳腺癌患者的治疗至关重要.
研究的目的:
- 评估炎症免疫营养评分 (IINS) 对乳腺癌患者术后生存和复发的预后意义.
- 将INS的预测性能与无进展生存期 (PFS) 和整体生存期 (OS) 的血小板与淋巴细胞比率 (PLR) 和预后营养指数 (PNI) 进行比较.
主要方法:
- 对200名接受初步手术治疗的女性乳腺癌患者进行了回顾性分析.
- 基于手术前高敏感性C反应蛋白 (hs-CRP),淋巴细胞 (LYM) 和白蛋白 (ALB) 水平的IINS的发展.
- 使用卡普兰 - 梅尔生存分析,接收器操作特征 (ROC) 曲线分析和Cox比例风险回归来评估预后值.
主要成果:
- IINS对PFS (曲线下的面积[AUC]: 0.735) 和OS (AUC: 0.738) 显示出强大的预测能力.
- 对于PFS和OS,IINS的预测准确度高于PLR和PNI.
- 危险比率表明IINS与生存结果之间存在显著的关联.
结论:
- 术前IINS是预测乳腺癌患者术后生存的可靠标志物.
- 与PLR和PNI等已知标志物相比,IINS可能具有更高的预后价值.
- 进一步验证IINS可以提高乳腺癌治疗的临床决策.
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