高压氧和类固醇用于防止大食道内学分离后的狭窄
Haotian Zeng1, Jiaxing Yang1, Ximin Lin1
1Gastroenterology, Shenzhen People's Hospital, Shenzhen, China.
Endoscopy international open
|August 27, 2025
概括
通过高压氧疗法 (HBOT) 辅助的类固醇可显著减少内镜下粘膜解剖 (ESD) 后的食道狭窄. 这种HBOT辅助的类固醇疗法提供了一种安全有效的方法来预防大食道病变的并发症.
科学领域:
- 胃肠病学
- 外科创新
- 高压医学
背景情况:
- 对大食道病变进行内镜下粘膜剖析 (ESD) 可能会导致狭窄.
- 在ESD后的食道狭窄是一个重要的临床挑战.
- 预防狭窄对于患者在ESD后的恢复至关重要.
研究的目的:
- 评估高压氧疗法 (HBOT) 辅助类固醇在预防食道狭窄方面的有效性.
- 通过HBOT辅助的类固醇治疗和不辅助的ESD后的狭窄发生率进行比较.
- 评估HBOT辅助类固醇治疗的安全性和不良反应.
主要方法:
- 针对大/长段食道粘膜缺陷进行ESD的35名患者的回顾性分析.
- 对照组接受了标准的类固醇治疗 (三素乙胺注射+口服普得尼松).
- 实验组除了接受标准类固醇治疗外,还接受了HBOT.
主要成果:
- 在HBOT组 (6. 7%) 与对照组 (40%) 的狭窄发生率显著降低.
- 在HBOT组中,周围缺陷的狭窄率为零,而对照组中为71. 4%.
- 其他ESD后并发症的发病率相似,并没有观察到与HBOT相关的不良事件.
结论:
- 通过HBOT辅助的类固醇治疗是预防ESD后食道狭窄的安全有效策略.
- 这种新的方法对管理大而长段的食道粘膜病变具有前景.
- 进一步的研究可能会巩固HBOT在术后食道护理中的作用.
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