帕金森病患者在不同疾病阶段的脑功能网络异常
Wei Wei1, Xinhui Wang1, Chao Han2
1Department of Radiology, Zhengzhou University People's Hospital and Henan Provincial People's Hospital, Zhengzhou, China.
Frontiers in neuroscience
|August 27, 2025
概括
在帕金森病 (PD) 中,大脑功能网络被破坏,变化因疾病阶段而异. 这些网络变化与临床严重程度相关,为PD进展提供了洞察力.
科学领域:
- 神经科学
- 医学成像
- 网络科学
背景情况:
- 帕金森病是一种神经退行性疾病,病因不明.
- 了解PD神经网络的变化对于诊断和治疗至关重要.
研究的目的:
- 通过静止状态功能磁共振成像 (rs-fMRI) 和图形分析,研究帕金森病不同阶段大脑功能网络拓学的变化.
- 在早期PD (PD-E),中期到晚期PD (PD-M) 和健康对照中比较大脑功能网络的拓特征.
主要方法:
- 招募了58名PD患者 (29名PD-E,29名PD-M) 和29名HC参与者.
- 使用rs-fMRI和图形分析来评估全球,区域和模块化大脑网络拓.
- 与临床评估相关的拓特征,包括MDS-UPDRS III和H&Y阶段.
主要成果:
- 与HC相比,PD患者 (PD-E和PD-M) 呈现出改变的全球网络拓,包括较低的集群系数.
- 在PD患者中,区域分析显示节中心性降低,默认模式和前侧状网络中心性增加.
- 在左中额头环和右中环的特定节点中心度与PD临床严重程度有关 (MDS- UPDRS III和H&Y阶段).
结论:
- 在帕金森病中,大脑的功能网络受到破坏,不同阶段的疾病都有不同程度的破坏.
- 这些发现增强了与PD严重程度相关的神经网络拓变化的理解.
- 这项研究强调了网络分析在特征病变的进展及其临床表现方面的潜力.
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