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在认知吞双任务范式中,迷走神经调制 (VNMM/taVNS) 的可行性:fNIRS试点研究
Zhiyong Wang1,2, Keling Cheng1, Junhui Bai1
1Department of Rehabilitation, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
非侵入性迷走神经刺激 (taVNS) 和VNMM在认知吞任务中显示出大脑网络调节的潜力. 这两种方法都增强了大脑激活和连接,
科学领域:
- 神经科学
- 生物医学工程
背景情况:
- 非侵入性迷走神经刺激 (taVNS) 和迷走神经磁调制 (VNMM) 是调制皮质网络的新兴技术.
- 它们在综合认知吞任务中的比较有效性在很大程度上尚未被探索.
研究的目的:
- 在双重任务模式中使用功能近红外光谱 (fNIRS) 评估taVNS和VNMM效应的可行性协议.
- 将taVNS和VNMM对这些任务中的皮质激活和功能连接的影响进行比较.
主要方法:
- 开发了一项涉及认知和吞任务的方案,参与者被随机分配到taVNS或VNMM组.
- 使用fNIRS获取干预前后的大脑活动数据.
- 通用线性建模 (GLM) 和基于种子的相关性分析评估了皮质刺激性和大脑连接性.
主要成果:
- 在认知和吞任务期间,taVNS和VNMM都显著增强了相关区域的大脑激活 (p < 0. 05).
- 这两种干预措施也改善了大脑半球内和半球间的网络连接.
结论:
- fNIRS是一个可行的工具,用于区分taVNS和VNMM在双重任务模式中的影响.
- 初步发现表明,与taVNS相比,VNMM可能提供更优质的网络调制,需要进一步调查.
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