自然产品通过调节炎症和氧化应激通路来缓解病毒性肺炎
Yifu Tie1,2, Han Liu3, Tong Zhang1
1Heilongjiang University of Chinese Medicine, Harbin, China.
Frontiers in pharmacology
|August 27, 2025
概括
通过调节炎症和氧化应激, 传统中医的天然产品为对抗病毒性肺炎提供了有前途的方法. 这些化合物有效地向关键路径,减少肺损伤并为新疗法提供基础.
科学领域:
- 综合医学
- 药理学
- 免疫学
背景情况:
- 病毒性肺炎会引起严重的炎症和氧化应激,可能导致急性呼吸困难综合征.
- 传统中医 (TCM) 提出了一种针对病毒性肺炎的多重治疗策略,毒性较低.
- 从TCM衍生的天然产品,如黄和多糖,在治疗病毒性呼吸道疾病方面具有潜力.
研究的目的:
- 对TCM治疗病毒性肺炎的天然产品进行最新研究.
- 阐明TCM天然产品调节炎症和氧化应激的机制.
- 为开发针对病毒性呼吸道感染的新疗法提供理论基础.
主要方法:
- 在PubMed,Web of Science和SciFinder进行了系统的文献搜索.
- 专注于过去十年内发表的研究.
- 关键词包括"病毒性肺炎"",传统中医"",天然产品"",炎症"",氧化应激",以及特定的信号通路 (NF-κB,Nrf2,PI3K/Akt,MAPK,NLRP3炎症体).
主要成果:
- 从TCM的自然化合物有效地准多种参与炎症和氧化应激的信号通路.
- 这些化合物表现出抑制细胞因子风暴和减少反应性氧物种的能力.
- 有证据表明,膜上皮的完整性得到保护,肺部炎症得到缓解.
结论:
- 来自TCM的天然产品调节病毒性肺炎的关键炎症和氧化应激途径.
- 这些发现支持基于TCM的新型抗炎和抗氧化疗法的开发.
- 通过提高安全性,TCM为治疗病毒性呼吸道疾病提供了一个有前途的途径.
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