在接受胃肠内镜检查的老年患者中,西普罗作为替代品的潜力:元分析和试验序列分析
Yunfeng Yu1, Min Liao2, Juan Deng1
1School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Frontiers in pharmacology
|August 27, 2025
概括
在接受胃肠内镜检查的老年患者中,西普罗福的安全性高于普罗福,减少了不良反应. 需要进一步的研究来确定对这一群体的最佳剂量.
科学领域:
- 麻醉学和胃肠病学
- 药理学和治疗学
背景情况:
- 在中国,Ciprofol越来越多地用于镇静和麻醉.
- 在接受胃肠内镜检查的老年患者中,其与普罗波的比较安全性尚未得到充分证实.
研究的目的:
- 在接受胃肠内镜检查的老年患者中,比较西普罗与普罗波的安全性.
主要方法:
- 对12项涉及1653名参与者的随机对照试验进行了系统审查和元分析.
- 使用八个数据库搜索到2025年1月1日的文献.
- 使用试验序列分析 (TSA) 和回归分析.
主要成果:
- 与普罗相比,西普罗显著降低了低血压,呼吸抑制,低氧,注射疼痛,非自愿运动和恶心/ 吐.
- 没有观察到诱导时间,唤醒时间,心肌梗塞或窒息咳的显著差异.
- 在低血压,呼吸抑制,低氧化和注射疼痛方面,TSA证实了确的差异.
结论:
- 对于接受胃肠内镜检查的老年患者来说,西普罗似乎是一种更安全的替代品,副作用较少.
- 对这一患者群体的最佳西普罗剂量需要进一步调查.
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