对重症肺炎的调整注射的有效性和安全性:系统性审查和元分析
Yan Wang1,2, Baichuan Xu1,2, Peng Zhang1,2
1National Regional Traditional Chinese Medicine (Lung Disease) Diagnosis and Treatment Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Frontiers in pharmacology
|August 27, 2025
概括
在重症肺炎患者中,Reduning (RDN) 注射提高了临床疗效. 这种传统中医的辅助疗法可以加速康复,减少发烧,咳和住院时间.
科学领域:
- 综合医学
- 肺病学
- 药理学
背景情况:
- 红色注射 (RDN) 是一种传统中医药 (TCM) 提取物,在中国作为严重肺炎 (SP) 的辅助疗法.
- 支持RDN注射在SP治疗中的疗效和安全性的临床证据需要系统验证.
研究的目的:
- 系统地评估Reduning (RDN) 注射作为严重肺炎 (SP) 的辅助治疗的有效性和安全性.
主要方法:
- 从多个数据库 (CNKI,WanFang,VIP,SinoMed,PubMed,Embase,Cochrane Library,Web of Science) 获取的随机对照试验 (RCT) 进行了一项元分析,截至 2024 年 4 月 6 日.
- 包括1897名多发性病患者的22项研究;主要结局是临床疗效.
- 使用柯克兰偏差风险评估工具2 (RoB2) 进行偏差风险评估.
主要成果:
- 与单独治疗相比,RDN注射与常规或抗生素治疗相结合显著改善了临床疗效 (RR = 1.25,95% CI [1. 20,1. 30].
- RDN注射缩短了发烧的持续时间 (MD = - 1. 55天),咳的消失 (MD = - 1. 97天),肺部疾病的解决 (MD = - 2. 39天),胸部X射线的改善 (MD = - 2. 73天) 和住院 (MD = - 3. 11天).
- 在APACHE II尺度上没有发现显著改善 (MD = - 2. 45分,p = 0. 19);报告了一些不良反应,但严重事件在所有研究中都没有一致记录.
结论:
- 通过注射RDN,可以作为SP的辅助疗法,改善临床结果并加速恢复.
- 这些发现表明,RDN注射可以改善关键的恢复指标,包括降低发烧,缓解咳和减少住院时间.
- 建议进行进一步的大规模,精心设计的临床研究,以证实这些发现和标准化治疗方案.
相关概念视频
Pneumonia IV: Management
447
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
447
Pneumonia V: Nursing management and Prevention
2.5K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.5K
Pneumonia III: Complications and Assessment
435
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
435
Drugs Used in Lower Respiratory Disorders: Overview
578
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
578
Pneumonia II: Pathophysiology
549
The pathophysiology of pneumonia involves the following steps:
549
COPD: Management Using Bronchodilators and Corticosteroids
307
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
307


