甲状腺结节中的三糖指数与恶性风险之间的关联:横截面分析
Xiuping Qiu1, Yang Chen1, Ruiyu Lin1
1Department of Endocrinology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, 364000,People's Republic of China.
Journal of inflammation research
|August 27, 2025
概括
甘油三糖 (TyG) 指数不是乳头甲状腺癌 (PTC) 的独立风险因素. 然而,代谢,甲状腺和免疫因素相互作用影响PTC的发展.
科学领域:
- 内分泌学
- 癌症学
- 代谢综合征
背景情况:
- 三甘油糖 (TyG) 指数是胰岛素耐药性的标志物.
- 胰岛素抵抗与包括甲状腺癌在内的各种癌症有关.
- 了解代谢因素对乳头甲状腺癌 (PTC) 风险的作用对于早期检测和预防至关重要.
研究的目的:
- 调查甘油三指数 (TyG) 与乳头甲状腺癌 (PTC) 风险之间的关联.
- 探索潜在的新陈代谢,甲状腺功能,以及这种关联的免疫机制.
主要方法:
- 一项对1833名参与者进行的横截面研究 (1010名PTC患者,823名良性甲状腺结节患者).
- TyG指数计算为 ln ((禁食甘油三) × 禁食葡萄糖/2).
- 使用多变量逻辑回归分析来评估TyG指数与PTC风险之间的关联,并对混因素进行调整.
主要成果:
- 经调整后,TyG指数不是PTC的独立风险因素 (调整后的OR=0.94).
- 中等水平的TyG与中年人的PTC风险增加有关 (OR=1. 45).
- 增加的FT3,降低的FT4和改变的TSH水平与PTC风险显著相关,同时与甲状腺自身抗体有复杂的关联.
结论:
- 单独的TyG指数并不是PTC的独立预测指标.
- 甲状腺功能障碍,甲状腺功能和免疫标记之间的相互作用在甲状腺致癌过程中至关重要.
- 这些发现为未来的研究和个性化查策略提供了洞察力.
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