怀孕期间的环境混合物和ECHO队列中的儿童睡眠质量
Sarah D Geiger1,2, Xiaoshuang Xun3, Cai Zhang1,2
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Frontiers in pediatrics
|August 27, 2025
概括
产前接触某些,如甲基,可能会对孩子的睡眠质量产生负面影响. 这些关联可以根据孩子的性别而有所不同,这突显了环境对早期发育的潜在影响.
科学领域:
- 环境健康
- 儿童睡眠科学
- 内分泌学
背景情况:
- 儿童睡眠质量会影响终身健康.
- 产前暴露于内分泌干扰化学物质 (EDC) 可能会影响胎儿的发育.
- 像类的EDC与成年人的睡眠障碍有关.
研究的目的:
- 研究产前度与儿童睡眠结果之间的关联.
- 确定特定的是否与儿童的睡眠问题,干扰或障碍有关.
- 探索儿童性行为改变这些关联的作用.
主要方法:
- 从2008年至2019年收集的NIH ECHO队列数据 (n=1,198) 的分析.
- 使用单一污染物和混合物模型来评估产前水平和儿童睡眠结果.
- 使用儿童行为检查表 (CBCL) 和PROMIS尺度测量儿童睡眠;检查了性别特异性相互作用.
主要成果:
- 较高的产前甲基度与较低的儿童睡眠障碍有关.
- 在男孩中,与睡眠障碍/ 睡眠障碍相关联的三和双A较强.
- 根据性别,没有发现混合物与儿童睡眠结果之间的总体关联.
结论:
- 产前暴露可能与儿童睡眠质量的改变有关.
- 婴儿的性别似乎是产前和睡眠结果之间关系的重要改变者.
- 这些发现强调了怀孕期间环境因素对儿童发育的重要性.
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