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胃腺癌中的FGF10表达与腺形成分化模式之间的关联:免疫组织化学分析

Seito Fujibayashi¹, Kazuhiro Kobayashi^2,3, Hiroyuki Tomita^2,4

¹Department of Gastroenterological Surgery and Pediatric Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

Oncology letters

|August 27, 2025

概括

纤维细胞生长因子 (FGF) 10 是胃腺癌形成腺体分化的标志物,有助于组织病理学分类. 然而,FGF10和FGFR2的表达与患者的存活率没有相关性,因此需要进一步研究.

科学领域:

癌症学
分子生物学
组织病理学

背景情况:

胃腺癌的分类会影响预后和治疗.
纤维细胞生长因子 (FGF) 10在胃形态发生过程中的作用已知,但其作为腺形成差异化的标记物的有用性尚不清楚.
了解分子标记可以完善组织病理学分类,并指导个性化治疗.

研究的目的:

研究胃腺癌中FGF10和FGF受体2 (FGFR2) 的表达.
评估FGF10和FGFR2表达和组织分化模式之间的关联.
探索FGF10/FGFR2表达与患者整体存活时间之间的关系.

主要方法:

对手术切除的117个胃腺癌样本进行免疫组织化学分析.
使用四级尺度评估瘤细胞和肌层中的FGF10和FGFR2表达.
多变量顺序逻辑回归以分析与差异化的关联,调整共变量.

主要成果:

增加的FGF10表达与分化良好,形成腺体的亚型显著相关,特别是中度分化的管状腺癌 (瘤细胞OR1. 749,P=0. 002;流体OR2. 418,P=0. 024).
FGFR2表达与分化模式没有显著的关联 (OR 0. 908,P=0. 788).
在FGF10或FGFR2表达和患者整体存活率之间没有发现显著的关系 (FGF10瘤细胞HR 0. 823,P=0. 127;FGF10瘤细胞HR 0. 675,P=0. 170;FGFR2瘤细胞HR 1. 080,P=0. 819).

结论:

在胃腺癌中,FGF10可作为一种有价值的分子标记物,用于形成腺体的分化,从而有可能完善组织病理学分类.
结果表明FGF10在开发个性化治疗策略的分层生物标志物中的实用性.
缺乏与生存的关联表明需要对FGF10的机制和临床意义进行进一步的研究.

关键词:

其他国家 FGFR2 在美国胃腺癌形成腺体的分化模式

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