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这页已由机器翻译。其他页面可能仍然显示为英文。View in English
  1. 首页
  3. 研究领域
  5. 生物医学和临床科学
  7. 瘤学和致癌症
  9. 预测和预后标志物
  11. 胃腺癌中的fgf10表达与腺形成分化模式之间的关联:免疫组织化学分析

胃腺癌中的FGF10表达与腺形成分化模式之间的关联:免疫组织化学分析

Seito Fujibayashi1, Kazuhiro Kobayashi2,3, Hiroyuki Tomita2,4

  • 1Department of Gastroenterological Surgery and Pediatric Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

Oncology letters
|August 27, 2025

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在PubMed 上查看摘要

概括
此摘要是机器生成的。

纤维细胞生长因子 (FGF) 10 是胃腺癌形成腺体分化的标志物,有助于组织病理学分类. 然而,FGF10和FGFR2的表达与患者的存活率没有相关性,因此需要进一步研究.

科学领域:

  • 癌症学
  • 分子生物学
  • 组织病理学

背景情况:

  • 胃腺癌的分类会影响预后和治疗.
  • 纤维细胞生长因子 (FGF) 10在胃形态发生过程中的作用已知,但其作为腺形成差异化的标记物的有用性尚不清楚.
  • 了解分子标记可以完善组织病理学分类,并指导个性化治疗.

研究的目的:

  • 研究胃腺癌中FGF10和FGF受体2 (FGFR2) 的表达.
  • 评估FGF10和FGFR2表达和组织分化模式之间的关联.
  • 探索FGF10/FGFR2表达与患者整体存活时间之间的关系.

主要方法:

  • 对手术切除的117个胃腺癌样本进行免疫组织化学分析.
  • 使用四级尺度评估瘤细胞和肌层中的FGF10和FGFR2表达.
  • 多变量顺序逻辑回归以分析与差异化的关联,调整共变量.

主要成果:

  • 增加的FGF10表达与分化良好,形成腺体的亚型显著相关,特别是中度分化的管状腺癌 (瘤细胞OR1. 749,P=0. 002;流体OR2. 418,P=0. 024).
  • FGFR2表达与分化模式没有显著的关联 (OR 0. 908,P=0. 788).
  • 在FGF10或FGFR2表达和患者整体存活率之间没有发现显著的关系 (FGF10瘤细胞HR 0. 823,P=0. 127;FGF10瘤细胞HR 0. 675,P=0. 170;FGFR2瘤细胞HR 1. 080,P=0. 819).
关键词:
其他国家FGFR2 在美国胃腺癌

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结论:

  • 在胃腺癌中,FGF10可作为一种有价值的分子标记物,用于形成腺体的分化,从而有可能完善组织病理学分类.
  • 结果表明FGF10在开发个性化治疗策略的分层生物标志物中的实用性.
  • 缺乏与生存的关联表明需要对FGF10的机制和临床意义进行进一步的研究.
形成腺体的分化模式