在精神分裂症和急性精神病中使用抗精神病药物延长QT间隔 - 一项前性研究
Anirban Saha1, Ajay Kumar1, Satyajit Singh2
1Department of Psychiatry, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Industrial psychiatry journal
|August 27, 2025
概括
抗精神病药物可以延长QT间隔 (QTIP),增加心脏风险. 这项研究发现7.5%至15.6%的精神分裂症患者患有QTIP,强调需要定期进行心脏监测.
科学领域:
- 精神病学
- 心脏病学
- 药理学
背景情况:
- 抗精神病药物与QT间隔延长 (QTIP) 相关,这是潜在致命心律失常和突然心脏死亡的危险因素.
- 了解QTIP的发病率和风险因素对于精神病治疗中的患者安全至关重要.
研究的目的:
- 在使用抗精神病药物两周后,确定精神分裂症和急性精神病患者的QTIP发病率.
- 确定与该患者群体中QTIP发展相关的潜在风险因素.
主要方法:
- 研究了160名被诊断为精神分裂症或急性精神病的成年患者,符合特定的纳入/ 排除标准.
- 在至少两周的抗精神病治疗之前和之后进行了心电图 (ECG),以计算纠正的QT间隔 (QTc).
- 使用弗里德里西亚和巴塞特的公式,QTIP被定义为男性的QTc> 450毫秒,女性> 460毫秒.
主要成果:
- 该研究包括160名患者,平均年龄为35. 88岁;55%是男性,86. 3%患有精神分裂症.
- QTIP的发生率为7.5% (弗里德里西亚公式) 和15.6% (巴塞特公式).
- 在研究样本中没有发现QTIP的其他风险因素.
结论:
- 在接受抗精神病药物治疗的患者中,QTIP是一个值得关注的问题,它影响了很大一部分参与者.
- 在接受抗精神病治疗的患者中,定期查和仔细评估风险因素至关重要,以减轻QTIP的风险.
更多相关视频
05:52Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
15.0K
12:00Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
Published on: November 19, 2014
13.0K
相关概念视频
01:26Psychosis: Goals of Pharmacotherapy
209
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
209
01:28Psychosis and Antipsychotic Drugs: Overview
454
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
454
01:21Antipsychotic Drugs: Typical and Atypical Agents
314
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
314
01:24Mania and Antimanic Drugs: Overview
319
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
319
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
947
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
947
01:28Drug Therapy
97
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
97