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相关概念视频

Dialysis01:27

Dialysis

477
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
477
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

78
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
78
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

129
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
129
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

183
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
183
Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

140
Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
140
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

105
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
105

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透析依赖与多发性骨髓瘤的预后不佳有关:多中心回顾性队列研究

Ji-Nuo Wang1,2, Chenyun Wang3, Jinping Ying4

  • 1Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang, China.

Therapeutic advances in medical oncology
|August 27, 2025
PubMed
概括
此摘要是机器生成的。

透析依赖多发性骨髓瘤 (MM) 患者的治疗结果不佳,但实现透析独立显著改善了生存率. 与更好的预后相关的因素包括VGPR,daratumumab和减少的无血清轻链.

关键词:
透析透析的独立性多发性骨髓瘤患有功能障碍生存时间

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科学领域:

  • 血液学
  • 肝脏病学
  • 癌症学

背景情况:

  • 多发性骨髓瘤 (MM) 与功能障碍 (RI),尤其是需要透析的病例,往往表现不佳.
  • 尽管有针对性的治疗进展,对透析依赖的MM和透析独立的因素的预后仍然不清楚.

研究的目的:

  • 分析中国透析依赖的MM患者的临床特征和治疗结果.
  • 确定影响该群体透析独立性和长期生存的因素.

主要方法:

  • 在122名慢性血液透析MM患者中进行的一项多中心,回顾性,实验性队列研究.
  • 用物流回归和卡普兰-梅尔/ 考克斯模型来分析透析独立性和生存率.

主要成果:

  • 在27%的患者中实现了透析独立;这些患者的无进展生存期 (PFS) 和整体生存期 (OS) 显著延长.
  • 与透析独立相关的因素包括非常好的部分反应 (VGPR),基于达拉图巴的治疗方案,显著的无血清轻链减少和65岁以下的年龄.
  • 在整个队列中,PFS的中位数为14. 4个月,OS的中位数为27. 4个月.

结论:

  • 透析依赖性MM患者的预后即使使用新疗法也很差.
  • 在患有功能障碍的MM患者中,实现透析独立是改善生存的关键因素.