使用时间域NIRS进行胎儿组织氧化水平的非侵入性监测
Zijing Guo1, Yongyi Zhao1, Yiyi Yang2
1Rice University, Department of Electrical and Computer Engineering, Houston, Texas, United States.
Journal of biomedical optics
|August 27, 2025
概括
这项研究引入了使用时间域近红外光谱 (TD-NIRS) 进行精确胎儿氧化监测的非侵入性方法. 开发的TD-NIRS系统显示出安全和准确的胎儿氧化水平评估的巨大潜力.
科学领域:
- 生物医学光学
- 医学成像
- 胎儿监测
背景情况:
- 胎儿氧化对于监测胎儿健康至关重要.
- 目前用于胎儿氧化监测的临床方法具有侵入性并带来风险.
- 需要使用非侵入性技术来评估胎儿的氧化量.
研究的目的:
- 开发和验证一种用于精确监测胎儿氧化的非侵入性方法.
- 使用时间域近红外光谱 (TD-NIRS) 进行准确的深层组织氧化评估.
- 证明TD-NIRS用于腹腔内胎儿监测的可行性.
主要方法:
- 使用时间域近红外光谱 (TD-NIRS) 来分离不同的组织层的光学特性.
- 使用蒙特卡洛模拟和双层组织幻影验证了该方法.
- 开发了一种基于纤维的TD-NIRS原型,并对人类前臂和孕母羊进行了体内实验.
主要成果:
- 在幻影实验中,TD-NIRS系统准确地估计了深层吸收系数.
- 原型系统成功检测出组织氧化指数 (TOI) 的变化.
- 在怀孕的母羊体内进行胎儿监测表明了该系统的潜力.
结论:
- 拟议的TD-NIRS方法可以进行深层组织氧化的非侵入性监测.
- 开发的原型显示出准确和安全的胎儿氧化评估的希望.
- 在怀孕和分娩期间改善胎儿健康监测的TD-NIRS技术具有重大潜力.
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