在患有硬化肌病的患者中,与利图西玛相关的大肠炎的内镜和组织病理发现
Roberto A Alvarado-Hernández1, Juan M Reyes-Morales1, Yoeli M Escandon-Espinoza1
1Gastrointestinal Endoscopy, Institute for Social Security and Services for State Workers (ISSSTE) - Hospital Regional De Alta Especialidad Bicentenario De La Independencia, Tultitlan, MEX.
Cureus
|August 27, 2025
概括
治疗自身免疫性疾病的利图西马布很少会导致新的性结肠炎. 对胃肠道症状的警和早期内镜评估对于迅速诊断和治疗这种罕见的不良反应至关重要.
科学领域:
- 免疫学
- 胃肠病学
- 癌症学
背景情况:
- 利图西马布是一种针对CD20+B淋巴细胞的仿制单克隆抗体,用于治疗血液恶性瘤和自身免疫性疾病.
- 虽然通常是安全的,但Rituximab使用与胃肠道不良反应有关,包括大肠炎.
- 一个罕见但有记录的并发症是新发炎性肠病的发展,即使没有先前的消化病史.
研究的目的:
- 突出西马布可能引发新的炎症性肠病.
- 强调微妙或重叠的症状所带来的诊断挑战.
- 强调早期内镜评估对抗CD20治疗的患者的重要性.
主要方法:
- 一个患有全身性硬化症的病人正在接受慢性修复药治疗.
- 胃肠道症状的临床,内镜和组织病理评估.
- 关于与rituximab相关的大肠炎和新发炎性肠病的文献综述.
主要成果:
- 患者患有大肠炎的特征与性大肠炎一致.
- 由于细微的症状与自身免疫性疾病的表现重叠, 诊断具有挑战性.
- 潜在的并发症包括狭窄,出血或穿孔,如果不及时发现.
结论:
- 在接受Rituximab的患者中,临床医生必须保持警持续的胃肠道症状.
- 通过活检进行早期内镜检查对于检测Rituximab诱导的大肠炎至关重要.
- 及时诊断和治疗可以减轻严重并发症的风险.
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