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使用乳房涂抹和用酸视觉检查的宫癌查及其与大肠镜检查的相关性

Eva Mishra¹, Ekta Chaudhary¹, Shweta Mishra¹

¹Obstetrics and Gynecology, Hind Institute of Medical Sciences, Sitapur, IND.

|August 27, 2025

概括

用乙酸 (VIA) 和帕帕尼科拉 (Pap) 涂抹进行视觉检查是有效的宫癌查工具. 在资源较少的环境中,VIA 提供高灵敏度的大规模查,而巴氏涂抹则提供更高的特异性和准确性.

科学领域:

妇科和产科
癌症学
公共卫生

背景情况:

宫癌是低收入和中等收入国家 (LMICs) 死亡的重要原因, 由于印度的检测延迟和查机会有限, 往往在晚期诊断.
这项研究旨在评估视觉检查用乙酸 (VIA) 和帕帕尼科拉 (Pap) 涂抹查方法的有效性以及它们与结肠镜评估的相关性.

研究的目的:

评估VIA和巴氏涂抹在检测子宫异常方面的诊断性能.
在资源有限的环境中比较VIA和Pap涂抹作为一线查工具的有效性.
分析查结果,肠镜检查和组织病理学发现之间的相关性.

主要方法:

这是一项前性观察性研究,涉及170名25至65岁的女性,为期18个月.
参与者接受了VIA和Pap查;如果Swede得分≥5,则异常结果导致结肠镜检查和组织病理学检查 (HPE) 的活检.
统计分析包括描述性统计,千二测试和诊断参数计算 (灵敏度,特异性,PPV,NPV,准确性).

主要成果:

在32. 9%的参与者中,VIA检测出异常,而在22. 9%的参与者中,帕普检测出异常.
结肠镜检查显示宫内皮质瘤 (CIN) 1 是最常见的发现 (48. 3%). 组织病理学证实CIN 2在50%和CIN 3在40%的活检病例.
VIA显示100%的敏感性和10%的特异性;帕普涂抹显示94.7%的敏感性和85%的特异性. 这两种方法都显示出具有统计学意义的关联与结肠镜和组织病理学发现 (p<0.05).

结论:

VIA和帕普查是对宫癌的有效查工具,而帕普查具有更高的特异性.
由于VIA的高灵敏度和易用性,使其适用于LMIC的大规模查,而在基础设施允许的情况下,Pap涂抹更准确.
一种分层查方法,从VIA开始,接着是阳性病例的帕普检查和大肠镜检查,可以改善早期检测和优化资源分配,为世界卫生组织2030年消除子宫癌的目标做出贡献.

关键词:

癌症子宫癌镜检查大规模选帕帕尼科拉测试乳头瘤病毒感染子宫的新生病阴道分泌物用酸进行视觉检查

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