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在患有外周动脉疾病的患者中使用甜菜汁的有效性:系统性审查
Carlos A Umaña Mejia1, Yolanda García Aguilar2, Yolik N Carracedo González3
1General Medicine, Universidad Autonoma De Guadalajara, Guadalajara, MEX.
Cureus
|August 27, 2025
概括
在外围动脉疾病患者中,甜菜汁可以提高运动能力和降低血压. 然而,目前的证据仅限于小型研究,需要进行更大规模的试验来确认.
科学领域:
- 心血管医学
- 营养科学
- 运动生理学
背景情况:
- 周围动脉疾病 (PAD) 是动脉样硬化的常见并发症,导致腿部疼痛和运动能力下降.
- 氧化 (NO) 对于血管健康至关重要;甜菜汁 (BRJ) 富含酸盐,是一种潜在的NO前体.
研究的目的:
- 系统地审查随机对照试验 (RCT) 对稳定PAD成人的BRJ的影响.
- 评估BRJ对运动能力 (结开始和步行高峰时间) 和血压的影响.
主要方法:
- 按照PRISMA 2020指南进行系统审查,搜索PubMed和ScienceDirect.
- 包含了五项已确认PAD和间歇性关节的RCT (64名患者).
- 评估缩开始时间 (COT),步行时间 (PWT) 和血压变化;评估偏差风险.
主要成果:
- 两项研究显示COT和PWT显著改善;其他研究报告两组均没有显著变化或改善.
- 三项研究发现压缩和压缩血压降低;两项研究报告血清酸盐/ 酸盐水平升高.
- 没有报告任何不良反应.
结论:
- 初步证据表明,BRJ可以通过提高运动能力和降低血压来使PAD患者受益.
- 结果受到小样本,研究设计的异质性,剂量,持续时间以及偏差的中等至高风险的限制.
- 需要使用标准化方案进行更大规模的长期RCT,以确认BRJ在PAD治疗中的临床效用.
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