肠-大脑轴:理解肠道微生物群变化与自闭症谱系障碍之间的相互联系
Anushka P Mishra1, Laura M Marrelli2, Felicia T Bonner-Reid3
1Medicine, Era's Lucknow Medical College and Hospital, Lucknow, IND.
Cureus
|August 27, 2025
概括
自闭症谱系障碍 (ASD) 与肠道失调有关,影响肠道-大脑轴. 针对肠道微生物群的新兴疗法在治疗自闭症症状方面显得有前途.
科学领域:
- 神经科学
- 微生物学
- 胃肠病学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种由遗传,环境和免疫因素影响的复杂神经发育状况.
- 微生物群-肠-大脑轴因其在自闭症病理生理学中的作用而越来越受认可.
- 胃肠道 (GI) 症状在患有自闭症的儿童中很常见,并且与行为问题相关.
研究的目的:
- 检查肠道疾病与自闭症之间的相关性.
- 探索肠道失调对自闭症管理策略的影响.
主要方法:
- 专注于自闭症的微生物群-肠道-大脑轴的文献综述.
- 分析研究的胃肠道症状,肠道透性,以及ASD中的失生症.
- 检查当前和新兴的治疗干预措施.
主要成果:
- 肠道失调与肠道透性增加有关,通过神经,免疫和内分泌途径破坏肠道-大脑轴.
- 失生导致炎症性细胞因子升高,神经递质产生变化,肠道代谢物发生变化.
- 诸如益生菌,益生菌,便微生物移植 (FMT) 和饮食修改等治疗方法具有潜力,但需要进一步研究.
结论:
- 由肠道微生物群调节的肠-大脑轴在自闭症中起重要作用.
- 针对肠道疾病的治疗策略为自闭症治疗提供了潜力.
- 进一步的研究至关重要, 以验证以肠道为中心的ASD干预措施的有效性和安全性.
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