影响COVID-19病毒清除的因素:疫苗接种和抗病毒治疗的影响
Jia Zeng1, Heping Xu1, Shuai Luo1
1Emergency Department of Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570311, People's Republic of China.
Infection and drug resistance
|August 27, 2025
概括
疫苗接种和抗病毒治疗对住院患者的COVID-19病毒清除有显著影响. 早期接种疫苗和尼尔马特雷尔维尔- 里托纳维尔治疗可以加速清除并减少住院时间.
科学领域:
- 传染性疾病
- 病毒学
- 临床医学
背景情况:
- 了解影响住院COVID-19患者病毒清除的因素对于有效的临床管理至关重要.
- 关键因素包括疫苗接种情况和抗病毒疗法.
- 优化患者的治疗结果取决于病毒清除的预测因素.
研究的目的:
- 研究疫苗接种和抗病毒治疗对住院COVID-19患者病毒清除的影响.
- 确定与病毒清除延迟相关的临床预测因素.
- 为了比较不同抗病毒疗法的病毒清除率.
主要方法:
- 在2022年3月至12月期间,对1,424名住院COVID-19患者进行了回顾性分析.
- 病毒清除定义为两个连续RT-PCR测试的间隔,Ct值≥35.
- 用于分析病毒清除预测因素的通用线性混合模型和强大的回归.
主要成果:
- 晚年,男性性别,高血压,冠心病,ICU入院和机械呼吸与病毒清除延迟有关.
- 接受≥2剂失活疫苗的患者的病毒清除速度更快,住院时间更短.
- 尼马特雷尔维尔- 里托纳维尔 (N/ R) 治疗比阿兹夫丁或没有抗病毒治疗更有效地加速病毒清除,导致住院时间更短.
结论:
- 住院COVID-19患者的病毒清除是多因素的,受人口统计,并发症,疫苗接种和抗病毒干预的影响.
- 给予≥2个失活的疫苗剂量,特别是在≥360天前,可能会增强病毒清除.
- 早期的尼尔马特雷尔维尔- 里托纳维尔 (N/ R) 治疗有望加速病毒清除并缩短住院时间.
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