患有同时发生的甲状腺髓癌和甲状腺膜癌的患者的临床病理特征和结果
Ruonan Sun1,2, Xueting Liu3, Jiabin Liu1,4
1Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in endocrinology
|August 27, 2025
概括
与单独使用MTC相比,骨髓甲状腺癌 (MTC) 和乳头甲状腺癌 (PTC) 的罕见共存显示出类似的侵袭性和预后. 这项研究分析了25名MTC和PTC患者,在关键病理特征或复发率上没有发现显著差异.
科学领域:
- 内分泌学
- 癌症学
- 外科病理学
背景情况:
- 甲状腺骨髓癌 (MTC) 和乳头甲状腺癌 (PTC) 是不同的甲状腺瘤.
- 同一个患者同时出现MTC和PTC是非常罕见的.
- 了解这种并存的临床病理影响对于患者的管理至关重要.
研究的目的:
- 分析MTC和PTC同时发生的患者的临床病理特征和预后结果.
- 将这些发现与仅用MTC诊断的患者进行比较.
主要方法:
- 从2009年1月到2024年5月,对25名同时接受MTC和PTC治疗的患者进行了回顾性分析.
- 组合组与仅使用MTC组之间的临床病理数据和随访结果的比较.
- 对人口,病理和预后变量进行统计分析.
主要成果:
- 结合组与MTC组之间没有观察到年龄,性别,MTC病变直径,多焦点性,甲状腺外延伸 (ETE),淋巴结 (LN) 转移或TNM阶段的统计学意义上的差异.
- 这两组的复发率相似.
- 在MTC组中,最大瘤直径和囊侵入被确定为生物化学/结构异常的显著独立预后因素.
结论:
- 与单独使用MTC相比,MTC和PTC的同时存在似乎不会改变侵袭性或预后.
- 最大瘤直径和囊侵入是MTC患者的关键预后指标.
- 进一步的研究可能会阐明这种罕见的双重诊断的具体管理策略.
相关概念视频
The Thyroid Gland
4.3K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.3K
The Parathyroid Glands
2.5K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.5K


