2型糖尿病中振动感知值估计的内脏脂肪区域和大神经纤维功能障碍之间的J形关系:横截面研究
1Department of Endocrinology, Ruijin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|August 27, 2025
概括
2型糖尿病患者内脏脂肪积累与神经损伤有关. 133. 9平方厘米的内脏脂肪面积显著增加了大神经纤维功能障碍的风险.
科学领域:
- 内分泌学
- 神经学
- 代谢综合征
背景情况:
- 肥胖是糖尿病外围神经病变 (DPN) 的已知危险因素,但确切的关系仍有争议.
- 内脏脂肪积累,是代谢功能障碍的关键指标,可能在DPN的发展中发挥关键作用.
研究的目的:
- 通过振动感知值 (VPT) 评估内脏脂肪区域 (VFA) 与大神经纤维功能障碍之间的联系.
- 为了澄清这种关系,中年和年轻的中国患者患有2型糖尿病 (T2DM).
主要方法:
- 对501名T2DM患者 (18至65岁) 进行了横截面研究.
- 使用生物电阻分析测量了内脏脂肪面积 (VFA).
- 使用振动感知值测量 (VPT) 评估大神经纤维功能障碍,并进行统计分析,包括多变量逻辑回归和平滑曲线拟合.
主要成果:
- 在VFA和VPT之间观察到非线性J形关联.
- 在133. 9cm2VFA时发现了显著的值效应.
- 超过133. 9厘米的VFA,每增加10厘米就会使异常VPT的风险增加22% (OR=1. 22).
结论:
- 在T2DM患者中,内脏脂肪积累和大神经纤维功能障碍遵循J形曲线.
- 超过133. 9厘米的VFA值显著增加神经功能受损的风险.
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