中性粒细胞CD64指数在糖尿病足骨髓炎的诊断价值
Haojie Sun1, Hao Heng1, Xuekui Liu1
1Department of Endocrinology, Xuzhou Central Hospital, Xuzhou, Jiangsu, 221009, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|August 27, 2025
概括
中性细胞CD64 (nCD64) 指数显示为诊断糖尿病足骨髓炎 (DFO) 的快速生物标志物. 将nCD64与红细胞沉积率 (ESR) 结合起来,进一步提高了DFO的诊断准确性.
科学领域:
- 生物化学
- 免疫学
- 糖尿病学
背景情况:
- 糖尿病足骨髓炎 (DFO) 是糖尿病的一个严重并发症.
- 早期和准确的DFO诊断对于有效的治疗和肢体挽救至关重要.
- 目前的诊断方法可能具有侵入性或缺乏早期检测的敏感性.
研究的目的:
- 评估中性细胞CD64 (nCD64) 指数作为一个新的,快速的DFO诊断生物标志物.
- 将nCD64指数的诊断性能与已确定的炎症标志物进行比较.
- 在DPO中评估nCD64指数和红细胞沉积率 (ESR) 的综合诊断值.
主要方法:
- 研究了142名患有2型糖尿病和糖尿病足部感染的住院患者.
- 患者被分为DFO (n=58) 和非DFO (n=84) 组.
- 测量和比较nCD64指数,WBC,CRP,PCT和ESR水平;进行了后勤回归和ROC曲线分析.
主要成果:
- 在DFO组中,nCD64指数显著更高 (P<0.05).
- 确定了nCD64指数和ESR作为DFO的独立风险因素.
- nCD64指数显示曲线下的高面积 (AUC) 为0. 895,敏感度为96. 6%;ESR的AUC为0. 846,特异性为82.1%.
- 结合nCD64指数和ESR,最佳AUC为0. 937,敏感度为86. 2%,特异性为91. 7%.
结论:
- nCD64指数是早期检测DFO的一个有前途的新生物标志物.
- 将nCD64指数与ESR结合起来可以显著提高DFO的诊断准确性.
- 这种方法为改善DFO诊断和管理提供了快速,非侵入性的工具.
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