Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Aging01:26

Aging

181
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
181
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

3.2K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
3.2K
Epigenetic Regulation01:46

Epigenetic Regulation

31.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.4K
Inflammatory Response01:28

Inflammatory Response

7.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
7.1K
Inflammation01:38

Inflammation

55.1K
Overview
55.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms.

Gut·2026
Same author

Enhancing the performance and interpretability of epigenetic clocks.

Nucleic acids research·2026
Same author

Integrated metabolomics and metagenomics reveal divergent caecal metabolic signatures following commercial gut health interventions in broilers.

Animal microbiome·2026
Same author

Meta-analysis of DNA methylation aging signatures in 17 human tissues.

Nature aging·2026
Same author

Association and risk prediction of 19 complex diseases with polygenic scores and socioeconomic status.

Communications medicine·2026
Same author

Targeting EP2/EP4-driven expansion of suppressive VSIG4<sup>high</sup> macrophages overcomes immunotherapy resistance in colorectal cancer.

Cell reports·2026

相关实验视频

Updated: Sep 10, 2025

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

7.6K

原生免疫细胞亚型的变异与表观遗传钟,炎症和健康结果相关

Xiaolong Guo1, Josephine A Robertson2, Andrea Aparicio3

  • 1Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 27, 2025
PubMed
概括

天生的免疫细胞转移和核化的红细胞会影响表观遗传时钟的生物年龄估计. 这一发现扩大了对血细胞异质性的理解

关键词:
DNA 甲基化生物标志物表观遗传时钟对健康的结果引起炎症原生免疫系统

更多相关视频

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.2K
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.6K

相关实验视频

Last Updated: Sep 10, 2025

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

7.6K
Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.2K
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.6K

科学领域:

  • 免疫学
  • 老年学
  • 表观遗传学

背景情况:

  • 血液中的表观遗传钟估计生物年龄, 与死亡率相关.
  • 之前的研究集中在适应性免疫系统对表观遗传时钟的影响上.
  • 天生的免疫系统异质性对表观遗传时钟的影响在很大程度上仍未被探索.

研究的目的:

  • 调查先天免疫细胞中的异质性如何影响表观遗传时钟的估计.
  • 探索先天免疫细胞转移,炎症和全因死亡之间的关联.
  • 检查核红细胞类细胞在健康结果中的作用.

主要方法:

  • 使用了19种免疫细胞的高分辨率DNA甲基化参考面板.
  • 包括单细胞,自然杀伤细胞和中性细胞的年轻和成年子组.
  • 使用转录组和代谢组数据验证了单细胞异质与炎症的相关性.

主要成果:

  • 原生免疫细胞亚型 (单细胞,NK细胞,中性细胞) 的变化与表观遗传时钟加速和炎症相关.
  • 单细胞异质性与炎症有关,通过多组数据进行验证.
  • 核化红细胞类细胞与炎症,红质形成功能障碍有关,是主要的死亡风险因素.

结论:

  • 在适应性免疫系统之外,先天性免疫细胞异质性会影响表观遗传时钟的准确性.
  • 本质免疫和红细胞样细胞的异质性与炎症和死亡有关.
  • 这些发现突出了血液细胞组成对生物衰老和健康结果的更广泛影响.