相关实验视频

Updated: Sep 10, 2025

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

HLA-B07:62:02 和 HLA-C07:02:165 的基因组序列

Maria Loginova^1,2, Nadezhda Morozova¹, Igor Paramonov¹

¹Federal State-Financed Scientific Institution, Kirov Research Institute of Hematology and Blood Transfusion Under the Federal Medical Biological Agency, Kirov, Russia.

|August 27, 2025

概括

已经确定了两个新型人类白细胞抗原 (HLA) 的序列,HLA-B*07:62:02和HLA-C*07:02:165. 这些发现为免疫学研究中不断增长的HLA基因序列数据库做出了贡献.

科学领域:

免疫遗传学
分子生物学

背景情况:

人类白细胞抗原 (HLA) 基因对免疫反应至关重要.
精确的HLA基因序列测定对于移植和疾病关联研究至关重要.

研究的目的:

报告两个特定的HLA基因的新确定的核酸序列.
扩大已知的HLA系统的遗传多样性.

主要方法:

使用高分辨率的序列类型.
使用了下一代测序技术.

主要成果:

确定了HLA-B*07:62:02等位基因的完整核酸序列.
确定了HLA-C*07:02:165等位基因的完整核酸序列.

结论:

这些新型HLA基因序列的表征为HLA参考库增加了有价值的数据.
这些信息可以帮助未来的高分辨率HLA类型和人口遗传研究.

关键词:

HLA-B 其他 HLA-C 其他没有NGS 新型基因组同义变异

更多相关视频

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

Genetic Lingo

Genetic Lingo

Genetic Variation

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...